Management of the Failed Total Ankle Replacement
 
Introduction
TAR survivorship is around 90% at 10 years on the national joint registry (89.6% at 13 years as max)
Latest NJR annual report (2024)
 
 
Causes of failure
 
 - infection
 
 - aseptic loosening
 
 - lysis / cyst formation
 
 - polyethylene failure:
 
  - wear
 
  - fracture
 
  - dislocation
 
 
  
 - malalignment / instability
 
 - stiffness
 
 - soft tissue impingement
 
 - unexplained pain
 
 
 
Diagnosis
 
 - History:
 
  - Pain, stiffness, instability, swelling, symptoms of infection
 
  - Are symptoms new, or been there since day 1?
 
  - Patient background
 
 
  
 
 - Examination:
 
  - Soft tissue (swelling, skin, scars, Achilles tendon)
 
  - Joint (mobility, stability)
 
  - Alignment (midfoot, hindfoot, ankle, lower limb overall)
 
 
  
 
 - Investigations:
 
  - Weight bearing ankle x-rays:
  
   - radiolucency >2mm and/or progression with time suggests loosening
 
   - >5 degrees or >5mm change in position in serial x-rays suggests migration
 
  
   
  - CT: bony morphology, quantify bone cysts
 
  - MRI: soft tissue collection / infection
 
  - SPECT / gallium scan: location of pain source / diagnose infection
 
  - Arthroscopic biopsy:
  
   - 5 micro sample and 2 histology samples
 
   - More accurate than aspiration
 
  
   
 
  
 
IDEALLY, CASES SHOULD BE DISCUSSED IN A MUTLIDISCIPLINARY TEAM MEETING FOR PATIENT MANAGEMENT AND SURGICAL PLANNING
 
 
Treatment options
 
Infection:
 - Mostly will be 2 stage revision
 
 - 1st stage revision with implant removal, thorough debridement, cement spacer
 
 - Eradication rates for 2 stage revision around 90%
 
 
Aseptic loosening / revision options:
 - larger units will have more experience
 
 - characterise degree and location of bone loss
 
 - options are:
 
  - revision with revision components (Inbone II / Invision)
 
  - salvage fusion (TTC with femoral head / impaction bone grafting / 3D printed cage)
 
  - total talus replacement with total ankle replacement (still early stages, last resort)
 
  - amputation
 
 
  
 
Poly wear / fracture / dislocation:
 - Poly wear usually leads to implant loosening  if loose then revision is the answer (see above)
 
 - If purely fracture / need poly exchange:
 
  - if still available then poly exchange
 
  - if not available then revision
 
 
  
 
Bone cyst: 
 - Usually from poly wear / infection: diagnose / exclude 
 
 - Treatment is curettage, take samples, and impaction bone graft (allograft mostly)
 
 - Check implant stability intraop
 
 
Stiffness / instability:
 - Poor evidence in literature
 
 - Broström repair if pure instability with stable and well aligned implants
 
 - Revision of components if they are the issue
 
 - MUA / arthroscopic arthrolysis / TA lengthening for stiffness  no evidence
 
 
Periprosthetic fracture:
 - Rare, implants stable most of the time
 
 - ORIF
 
 
Outcomes:
 - Revision TAR  27% needed further surgery, 14% needed another revision
 
 - Salvage fusion  87% union rate, 13% needed further surgery, 8% revision surgery
 
 
 
Prevention of failed TAR
 
Choose the optimal patient:
 - older patient or one with lower physical demands
 
 - good alignment and ligamentous stability
 
 
Avoid poor patient choice:
 - neuromuscular deformity
 
 - previous infection
 
 - poor soft tissues / vascularity
 
 - osteonecrosis / osteoporosis may cause problems with bony fixation
 
 - poor host
 
 
Choose the optimal surgeon:
 - implant-trained, higher volumes
 
 - supportive infrastructure and colleagues, research team
 
 - access to complex case MDT
 
 - regional network for revision cases
 
 
 
Conclusion
 
 - 90% survival at 10 years
 
 - Most reported complications are preventable with good patient selection and surgical technique
 
 - Failed TARs need appropriate investigation, work-up and team discussion before proceeding with appropriate revision / salvage options
 
 - The solution should be tailored to the clinical scenario (i.e. no one-size-fits-all algorithm)
 
 
 
MCQ
 
What is the main priority in working up a possible failing total ankle replacement?
 - 
 
  - Exclude infection
 
  - Identify and quantify bone defects
 
  - Send the patient to physiotherapy to optimise function before proceeding
 
  - Check for signs of loosening
 
  - Discuss case at MDT
 
 
  
 
 
References
 - Clarke MJH, Salar O, Evans JP, Bayley MGR, Waterson BH, Toms AD, Phillips JRA. Prosthetic joint infection of the knee - arthroscopic biopsy identifies more and different organisms than aspiration alone. Knee. 2021 Oct;32:183-191. doi: 10.1016/j.knee.2021.08.016. Epub 2021 Sep 6. PMID: 34500431.
 
 - Antonio Izzo, Claudia Carbone, Vincenzo De Matteo, François Lintz, Enrico Festa, Giovanni Balato, Alessio Bernasconi, Eradication rate after debridement, antibiotics, and implant retention (DAIR), 1.5-stage revision or 2-stage revision in periprosthetic ankle joint infection: A systematic review, Foot and Ankle Surgery, 2025
 
 - Jennison T, Spolton-Dean C, Rottenburg H, Ukoumunne O, Sharpe I, Goldberg A. The outcomes of revision surgery for a failed ankle arthroplasty. Bone Jt Open. 2022;3(7):596-606. doi:10.1302/2633-1462.37.BJO-2022-0038.R1
 
 - Lee MS, Lee GW, Lee KB. Bone grafting for periprosthetic bone cysts following total ankle arthroplasty. Bone Joint J. 2024 May 1;106-B(5):475-481. doi: 10.1302/0301-620X.106B5.BJJ-2023-1091.R1. PMID: 38688515.
 
https://www.orthobullets.com/foot-and-ankle/12133/total-ankle-arthroplasty